101 Misleading results from Vivisection
70: Animal Visctims Escalate after ICI Drug Fails
During clinical trials, ICI's arthritis drug fenclozic acid unexpectedly produced jaundice in some of the patients. Researchers were surprised since tests with rats, mice, dogs and monkeys had given no hint of liver problems.(1) Not content with these results, further experiments with rabbits, guinea pigs, ferrets, cats, pigs, horses, neonatal rats and mice, together with a different strain of rat, were carried out but still no evidence of liver damage could be found.(1) The ICI researcher commented that “The quite unexpected onset of jaundice in a few patients caused withdrawal of the drug from humans and initiated a vast programme of experimental work. This search for hepatotoxicity (liver damage) in different species or any indication of its likelihood has so far been unrewarding."(1)
References
1) S.J.Alcock, Proceedings of the European Society for the Study of Drug Toxicity, 1971, vol.12, 184-190.
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